Abstract 10677: A Validation of Circumferential and Longitudinal Regional Strain in Pumped Hearts Modeling Normal Function Compared to Simulated Myocardial Infarction Generated From Three-Dimensional Echocardiographic Feature Tracking Compared to Sonomicrometry
Background: Three-dimensional (3D) echocardiography provides visualization of the complex anatomy of heart structures throughout the cardiac cycle. Quantitative global and regional strain values may be obtained from 3D echo data via semi-automated feature-tracking and the corresponding myocardial deformation measurements have been shown to be indicative of function. We aimed to validate a 3D/4D strain analysis program developed by GE for strain determination compared to sonomicrometry in a pumped heart model.
Methods: Ten adult pig hearts were passively pumped to simulate normal cardiac motion at stroke volumes (SV) varying from 30-70ml. In 6 of the hearts, 2ml glutaraldehyde was injected in the mid-anterior (MA) segment to simulate a myocardial infarction (MI). A 3V-D matrix probe interfaced with a GE Vivid E9 ultrasound system was used to image each heart. The 4D LVQ function of EchoPac was used to quantify the circumferential and longitudinal strain (CS, LS) at MA at each SV pre- and post-MI. Strain values were compared to the relative displacement of sonomicrometry crystals.
Results: Linear regression showed excellent correlation in both LS and CS between the 3D echo and sonomicrometry with R2 values of 0.88 and 0.67, respectively. Bland-Altman plots for LS and CS validate that both methods acquire comparable values. It was also determined that EchoPAC was able to detect a decrease in LS and CS between pre- and post-MI at all SVs. Strain values in the MI regions were diminished when compared to control regions.
Conclusions: The 4D LVQ function of EchoPac is a robust utility with the ability to accurately obtain quantitative regional strain values from 4D echo volumes.
- © 2011 by American Heart Association, Inc.