Abstract 10624: Efficacy of ABSORBTM Bioresorbable Vascular Scaffold Implantation in Atherosclerotic Pigs
Objective: Long-term vascular integration of everolimus-eluting ABSORBTM Bioresorbable Vascular Scaffold (BVS) has been reported in healthy pigs. However, the efficacy of ABSORB BVS during the 3-6 months restoration phase has not been studied in a diseased animal model. This could be relevant for clinical application in patients with coronary artery disease.
Methods: Nine months after induction of atherogenesis, coronary arteries of 15 swine were imaged by Optical Coherence Tomography (OCT) and 32 ABSORB BVS were implanted on top of lesions (balloon/artery ratio: 1.12±0.06). Follow up (FU) after intervention was 3-6 months. Vessel segments proximal and distal to the scaffold and of non-BVS vessels were isolated. In vitro endothelium-dependent and -independent vasodilation to bradykinin (BK) (with or without NO-synthesis inhibition) and nitrates, as well as vasoconstriction to endothelin-1 (ET-1) were assessed.
Results: At implantation, angiography showed 5±4% acute recoil and no dissections. OCT showed complete scaffold apposition (99%) acutely, and no tissue prolapse or late malapposition at FU. Moreover, all ABSORB BVS remained patent up to 6 months with late loss being 1.05±0.26 and 1.12±0.25mm at 3 and 6 months respectively. However, coronary segments distal to ABSORB BVS showed reduced BK-induced, NO-dependent vasodilation as compared to proximal and non-BVS vessel-segments (P<0.01). Moreover, ET-1 responsiveness was increased (P<0.01), whereas vascular smooth muscle cell function was unaffected by this new type of coronary intervention.
Conclusion: Six months of ABSORB BVS implantation shows good efficacy in an atherosclerotic pig model. However up to this time-point, ABSORB BVS causes distal NO-mediated endothelial dysfunction as compared to non-BVS vessel segments. This phenomenon has also been reported for currently used drug-eluting stents.
- Coronary artery disease
- Interventional studies
- Drug eluting stents
- Endothelial function
- Coronary vessels
- © 2011 by American Heart Association, Inc.