Abstract 10589: Univentricular Hearts in Denmark 1977-2009: Decreasing Incidence, Improving Survival, and Several Predictors of Survival
Introduction: The purpose of this national population-based study was to describe changes in incidence and survival in functional univentricular heart (UVH) patients in Denmark from 1977 to 2009.
Hypothesis: We hypothesized that incidence of UVH patients born alive decreased while termination of pregnancy (TOP) due to UVH diagnosed in the fetus increased. Furthermore, that survival improved throughout the period and predictors of survival could be identified.
Methods: Using nationwide registries we identified and obtained data on all UVH patients and TOP due to UVH in the fetus diagnosed in Denmark from 1977 to 2009. All diagnoses were confirmed through different local registries or review of medical files. If UVH could not be confirmed the patient was excluded.
Results: 822 cases were identified in the period, of these 106 TOP. The total incidence of UVH was stable during the period (mean: 0.40 UVH per 1000 births/TOP, SD 0.056). Incidence of UVH patients born alive, however, decreased considerably in the last part of the period. Kaplan-Meier curves for UVH patients by birth era showed an increase in survival in the period (Figure 1). We examined the effect of possible predictors on survival (Table 1). In the adjusted Cox proportional-hazards regression model type of UVH, birth era, extracardiac anomaly, birth weight, gestational age, and place of birth were independent predictors of survival.
Conclusions: In conclusion, incidence of UVH patients born alive is decreasing. Survival improved in the period and predictors of survival were identified.
- © 2011 by American Heart Association, Inc.