Abstract 10576: Markers of Periodontal Disease Predict Myocardial Infarction, Stroke and Heart Failure Differently in a Cohort of 7999 Subjects
Objective: Oral health has been associated with an increased risk for different cardiovascular disorders. So far, however, no study has investigated oral health in relation to the three most common cardiovascular diseases in the same cohort. The aim of the study was to investigate if different markers of periodontal disease relate to the three most common cardiovascular disorders, myocardial infarction, and stroke in different ways.
Material and method: Seven thousand nine hundred and ninety nine subjects, referred to a specialist clinic for periodontal treatment between 1976 and 2008, received a full mouth dental investigation including x-ray. Number of remaining teeth (NT), periodontal severity index (PDSI), number of deepened periodontal pockets (NDP), and bleeding on probing (BOP) were evaluated in relation to fatal/non fatal myocardial infarction (MI), heart failure (HF), and stroke.
Results: During a median follow up time of 13.6 years, 414 events involved fatal/non fatal MI; 204 involved HF; and 438 involved a stroke. Possible associations to above mentioned oral parameters as independent variables were investigated using three multivariate models with three cardiovascular endpoints as dependent variables. When comparing the highest quartile with the lowest one, and adjusting for age, gender, smoking as well as education level, both NT and NDP related significantly to MI (HR 1.69, 95% CI 1.02-2.81, and HR 1.53, 95%CI 1.03-2.27, respectively). NT was also related to HF (HR 2.52, 95% CI 1.20-5.28), while fatal/non fatal stroke was only predicted by BOP (HR 2.13, 95%CI 1.48-3.05).
Conclusion: Markers of periodontal disease predict future common cardiovascular events in different ways, suggesting that they are risk indicators for different cardiovascular disorders.
- © 2011 by American Heart Association, Inc.