Abstract 10544: Cocoa Increases Plasma Epicatechin Concentrations in Hyperlipidemic Children Without Adverse Effects on the Lipid Profile or Markers of Oxidative Stress
Background: Elevated serum cholesterol in childhood is associated with increased risk of coronary artery disease (CAD) in adulthood and diet is first-line therapy. Observational studies suggest dietary flavonoids reduce the risk of CAD. The cardioprotective effects of flavonoids may be due to their antioxidant and anti-inflammatory properties. We determined the effect of a National Cholesterol Education Program Step II (NCEP-II) diet and cocoa on lipids and biomarkers in hyperlipidemic children.
Methods and Results: In a randomized, double-blind, placebo-controlled trial, 12 children (7-17 yrs) with familial hypercholesterolemia or familial combined hyperlipidemia consumed a NCEP-II diet for 6 wk and were then randomized to cocoa (300 mg flavanols) or placebo beverage (250 mL, 32 mg flavanols) daily for 6 wk. This was followed by 6wk washout and cocoa/placebo phases while on the NCEP-II diet. Plasma lipids were determined by enzymatic methods; F2-isoprostanes by GC/MS; epicatechin by HPLC; and LDL oxidation by Cu2+-induced reaction. Cocoa consumption increased plasma epicatechin status (p<0.001). Levels of TC, LDL-C, HDL-C, TG, and F2-isoprostanes as well as the resistance of LDL to oxidation were not significantly changed compared to placebo (Table). BP (114±9/61±8) and BMI (21±5) were not significantly affected by diet or cocoa intake.
Conclusion: Daily cocoa consumption increases plasma epicatechin in hyperlipidemic children without adverse effects on the lipid profile or biomarkers of oxidative stress. Future research on the effect of cocoa flavonoids on CAD risk factors in children is warranted, particularly directed to the form, dose, and duration of the intervention.
- © 2011 by American Heart Association, Inc.