Abstract 10522: Changes in Prevalence and Risk Factors of Acute Myocardial Infarction in the Rural and Urban District in Japan -Report from MIYAGI-AMI Registry Study
Background: The MIYAGI-Acute Myocardial Infarction (AMI) Registry Study has prospectively registered all AMI patients in the Miyagi prefecture, which is located in northeastern Japan and includes Sendai City with approximately ∼40% of 2,360,000 residents of the prefecture. We examined whether industrialization, urbanization and life-style changes have affected the prevalence and risk factors of AMI from 1998 to 2009, with a special reference to the difference between the urban and rural district of Japan, which is racially homogeneous with the highest rate of aging.
Methods and Results: A total of 12,491 AMI patients (male/female 8,969/3,522, age; 68.5±13.5 years) were registered from 43 hospitals and were divided into 2 groups, according to the residence inside (U, urban; n=4,276) or outside (R, rural; n=6,953) of Sendai City. In 1998-2001, the age-adjusted incidence of AMI (/100,000 persons/year) was lower in the rural district than in the urban district (U33.4±2.6 vs. R25.7±3.8, P<0.05). However, by 2009, it was increasing in the rural district (Figure A) and this tendency was evident especially in the male aged <65 years old (21.1±1.6 in 1998-2001, 26.2±1.5 in 2002-2005, 28.6±4.7 in 2006-2009, linear trend with P=0.03) (Figure B). Among coronary risk factors, the prevalence of dyslipidemia was only different and significantly lower in the rural district than in the urban district in 1988-2001 (U31.8±2.6% vs. R22.9±3.7%, P<0.01) (Figure C). The prevalence of dyslipidemia was progressively increasing in the rural district to approximately 2-folds (R41.1±7.8% in 2006-2009), especially in the male aged <65 years old (31.1±5.0% in 1998-2001, 41.7±3.0% in 2002-2005, 53.8±10.5% in 2006-2009, linear trend with P=0.007) (Figure D).
Conclusions: The MIYAGI-AMI registry study demonstrated the increased tendency of AMI prevalence in the rural district in Japan, which may be caused by the increased prevalence of dylipidemia in relatively young population.
- © 2011 by American Heart Association, Inc.