Abstract 10513: Cardiac Troponin T Measured by a Highly Sensitive Assay is Associated with Atrial Fibrillation in the General Population
Background: Predisposing factors of atrial fibrillation (AF) include cardiac remodeling, e.g. atrial dilatation and left ventricular hypertrophy. New high-sensitive cardiac troponin T (hsTnT) assay enables us to detect latent myocardial damage. Purpose: We examined whether hsTnT levels were associated with AF in the general population.
Methods and Results: We analyzed 224 subjects (67.4±9.4 years, 94 males) who received a health examination in a small community (Uku town, Nagasaki, Japan) in 2010. Twelve subjects were diagnosed as having AF based on an electrocardiogram. hsTnT was detected in 132. Compared with non-AF group, AF group had greater hsTnT, BUN, echocardiographic left atrial dimension (LAD), and lower estimated glomerular filtration rate (eGFR). Logistic regression analysis showed that hsTnT, LAD, and eGFR (inversely) were associated with AF. Step-wise logistic regression analysis showed that LAD (relative risk [RR]=1.314, p<0.001) and hsTnT (RR=4.576, p=0.015) were independent factors for AF. To determine associations of hsTnT levels with AF and other factors, we divided the subjects into four hsTnT categories (C1: <0.003ng/dL, n=92; C2: 0.003-0.007ng/dL, n=63; C3: 0.008-0.013ng/dL, n=51; C4: 0.014ng/mL [a 99th-percentile cutoff point] or more, n=18). The prevalence of AF was closely correlated with hsTnT levels (Figure A). One-way ANOVA showed that AF, age, systolic blood pressure, eGFR (inversely), uric acid, LAD, and left ventricular mass index were significantly associated with hsTnT categories. After adjustments for these factors using ANCOVA, hsTnT level was significantly greater in AF subjects than in non-AF subjects (Figure B).
Conclusion: In this population, hsTnT levels were significantly associated with AF. Therefore, hsTnT may be a candidate for predicting AF. Further investigation in a larger cohort is necessary to determine the causal relationship between hsTnT and AF.
- © 2011 by American Heart Association, Inc.