Abstract 10507: Does Hyperoxia Impact Cardiac Arrest Survivors Treated with Therapeutic Hypothermia?
Background: Recent studies have demonstrated that presence of hyperoxia following resuscitation from cardiac arrest (CA) is associated with increased mortality. We sought to investigate the impact of hyperoxia among CA survivors treated with therapeutic hypothermia (TH)
Methods: We identified 88 consecutive patients who underwent TH between 3/2007 - 8/2010. Inclusion required a Glascow Coma Scale < 8 and time of return of circulation (ROC) to TH induction < 4 hours. Patients with hypoxemia (arterial oxygen saturation <60 mmHg, N=6) were excluded. Cooling was achieved with a central venous catheter. Multivariable Cox proportional analysis was used to calculate adjusted hazard ratios (AHR) on the combined incidence of death and poor neurologic recovery by the presence of hyperoxia (≥ 300 mmHg, N=20) or normoxia (60- 299 mmHg, N=62)
Results: Patients with hyperoxia were similar to those with normoxia, mean age 60 ± 13 vs 59 ± 16 years (p=0.71), incidence of shockable rhythms 50 vs 50% (p=1.0), ROC time 23 ± 14 vs 20 ± 12 minutes (p=0.39). Presence of hyperoxia was not associated with a difference in incidence of death or poor neurologic recovery [AHR 1.75 (95% CI 0.88 - 3.49) p=0.11, figure] when compared to normoxia. Upon propensity matching for age, time to ROC and shockable CA, hyperoxia was not associated with a significant difference in outcomes [AHR 1.48 (95% CI 0.64 - 3.44) p=0.36]
Conclusion: Hyperoxia is not associated with an adverse outcome among cardiac arrest survivors treated with therapeutic hypothermia
- © 2011 by American Heart Association, Inc.