Abstract 10298: The Degree of Hyponatremia is a Strong Prognosticator in Patients Admitted with Diastolic Heart Failure
Introduction: Although hyponatremia has been shown to be a predictor of adverse outcomes in patients admitted with heart failure (HF), the effects in patients with diastolic HF have not been comprehensively investigated.
Hypothesis: We assessed the hypothesis that not only hyponatremia, but the degree of hyponatremia, may be used as a predictor of adverse outcomes in patients admitted with diastolic HF.
Methods: Using medical quality surveillance software, we conducted a retrospective cohort study over a 2 year period examining the data of patients admitted to our institution with the diagnosis of HF and a documented EF greater than 50%. All patients who met inclusion criteria were analyzed in groups based on their sodium levels at the time of admission. The outcomes investigated included average length of stay, readmission rates and mortality.
Results: A total of 6681 patients met the criteria for analysis. In general, hyponatremia was found to be a strong predictor of negative outcomes as the average length of stay, readmission rates and mortality were found to significantly increase inversely to serum sodium levels. Readmission rates were not significantly different in the <125meq/L group, likely secondary to the number of patients. Mortality at 1, 2 and 3 years was significantly highest in the 126 to 130 meq/L group but otherwise increased inversely to sodium levels. See figures for full results.
Conclusion: In conclusion, not only are initial sodium levels a powerful predictor of length of stay, readmission rates and both short and long term mortality in patients admitted with diastolic HF but the degree of hyponatremia can be used to further risk stratify these patients.
- © 2011 by American Heart Association, Inc.