Abstract 10224: Common Carotid End-Diastolic Velocity is Independently Associated with Future Ischemic Heart Disease in Taiwan
Background and Purpose Our previous prospective study showed that low end-diastolic velocity (EDV) in common carotid artery, a potential hemodynamic marker of intracranial resistance, was associated with ischemic stroke. We investigated that whether the end-diastolic velocity was also associated with incident ischemic heart disease (IHD) in an Asian population.
Methods Baseline data from 3170 adults (30 years or older) in the Cardiovascular Diseases Risk Factor Two-Township Study were linked to incidental ischemic heart disease (ICD-9-CM: 410-414) status derived from insurance claims and death certificate records. Hazard ratios for risk of ischemic heart disease for EDV values measured in common carotid artery were calculated using Cox proportional hazard models.
Results With 9.84 years (median) of follow-up, 138 persons had ischemic heart disease develop. A dose-response relationship (inverse association) was found in univariate analysis between IHD risk and tertiles of peak systolic velocity (hazard ratio and 95% confidence intervals: 2.72 [1.75-4.24] for lowest group; 1.79 [1.12-2.87] for middle group; p-value for trend <.0001), EDV (5.74 [3.30-10.0] for lowest group; 2.99 [1.68-5.33] for middle group; p value for trend <.0001). Only EDV was associated with future IHD in the multivariate model. A 108% increase (2.08, 1.02-4.23) in IHD risk was observed for individuals with EDV< 15 cm/sec compared with those EDV ≥ 20 cm/sec.
Conclusions Low common carotid EDV is independently associated with future IHD in this Taiwanese population. More prospective studies are required in various ethnic groups to understand the significance and implication of the current findings.
- © 2011 by American Heart Association, Inc.