Abstract 10219: The Prognostic Value of the Ratio of Eicosapentaenoic Acid to Arachidonic Acid in Patients with Acute Coronary Syndrome
Background: The ratio of eicosapentaenoic acid (EPA) to arachidonic acid (AA) is a predictor of cardiac event in patients with chronic coronary artery disease and favorite effect of intake of EPA on outcome in these patients has been demonstrated; however, the prognostic significance of EPA/AA ratio in acute coronary syndrome (ACS) has not been determined.
Methods and results: 75 patients with ACS were enrolled in this study (68±13 years, 59 male). Percutaneous coronary intervention (PCI) was performed in all cases within 24 hours from admission. EPA/AA ratio was measured at the time of admission. Patients were divided into two groups according to the median of EPA/AA ratio: high EPA/AA group (EPA/AA>0.4), low EPA/AA group (EPA/AA<0.4). The clinical variables at baseline, PCI results and clinical outcome during the follow-up period were compared between the two groups. Compared to high EPA/AA group, low EPA/AA group had higher incidence of dyslipidemia. Coronary intervention was performed successfully in all patients; however, low EPA/AA group had higher incidence of complication including side branch occlusion and distal embolism than high EPA/AA group (10% vs 0%, p<0.05). During the follow-up period (mean 378 ± 222 days), target lesion revascularization (TLR) rate was comparable between the two groups (18% vs 25%, p=0.45); however, the rate of PCI to new lesion was higher in low EPA/AA group than in high EPA/AA group (28% vs 11%, p<0.05).
Conclusion: It is suggested that EPA/AA ratio is a significant predictor of short- and long-term cardiac event in patients with ACS.
- © 2011 by American Heart Association, Inc.