Abstract 10193: Oxidative and Inflammatory Markers in Relation to Circulating Levels of Adiponectin
Background: There is some evidence to support an association between adiponectin, oxidation and inflammation, but community-based studies investigating the relative importance of oxidative and inflammatory markers in relation to adiponectin are lacking.
Methods: In a cross-sectional sample of 929 70-year old individuals (50% women) of the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study, we investigated relations between serum adiponectin and oxidation (conjugated diens, homocysteine, total antioxidant capacity, oxidized LDL [oxLDL], oxLDL antibodies, conjugated dienes of LDL, glutathione [GSH], total glutathione [TGSH], glutathione disulfide), interleukins (IL-2, IL-6, IL-8), other cytokines (tumor necrosis factor-alpha, monocyte chemoattractant protein-1 [MCP-1], epidermal growth factor [EGF], vascular endothelial growth factor, CD40L), cell adhesion molecules (vascular cell adhesion molecule-1, intercellular adhesion molecule-1, E-selectin, P-selectin, L-selectin), and systemic inflammatory markers (C-reactive protein [CRP], leukocyte count).
Results: In models adjusted for age and sex, adiponectin was positively associated with GSH and log TGSH, and inversely associated with conjugated diens, MCP-1, log EGF, log E-selectin and log CRP. In multivariable models (additionally adjusting for BMI, smoking, HOMA-IR, medication against diabetes, hypertension and hyperlipidemia, total cholesterol, HDL, triglycerides, and estimated glomular filtration rate), adiponectin remained associated with GSH (beta, 20.4; 95% CI, 6.8, 34.1; P, 0.003), log TGSH (beta, 0.02; 95% CI, 0.00, 0.03; P, 0.020), conjugated diens (beta, -0.81; 95% CI, -1.46, -0.16; P, 0.015), and log EGF (beta, -0.08; 95% CI, -0.15, -0.01; P, 0.033). Further, we found that these associations were more pronounced in patients with known CVD compared with healthy individuals (∼2 to 4 times larger effect sizes).
Conclusion: In our study of community-dwelling elderly individuals, we observed pronounced associations of adiponectin with several markers of inflammation or oxidation. The stronger associations in individuals with prevalent CVD indicate that the pathways involved could possibly be up-regulated in CVD patients.
- © 2011 by American Heart Association, Inc.