Abstract 10140: Effects of Serum Eicosapentaenoic Acid on Vascular Inflammation and Endothelial Dysfunction in Japanese Hemodialysis Patients
Cardiovascular disease (CVD) is the most common cause of death in hemodialysis (HD) patients. Many reports have documented beneficial effects of dietary intake of eicosapentaenoic acid (EPA), a major omega-3 fatty acid, on the prevention of CVD. However, it is still unclear whether serum level of EPA affects the vascular endothelial function in HD patients. The aim of the present study was to investigate the effects of serum EPA level on the vascular inflammation and endothelial dysfunction in Japanese HD patients.
We recruited 42 stable Japanese HD patients who had taken ordinary diet for chronic renal failure. Patients with diabetes mellitus, coronary heart disease, malignancy, or significant malnutrition, or those with regularly taking a fish oil supplement were excluded. Serum levels of arachidonic acid (AA) and EPA were measured after overnight fasting and the EPA/AA ratio was calculated. We also measured plasma pentraxin 3 (PTX3), serum interleukin-1 (IL-1) and serum high-sensitivity C-reactive protein (hs-CRP) as parameters of vascular inflammation, and assessed the endothelium-dependent flow-mediated dilatation of brachial artery (FMD) and cardio-ankle vascular index (CAVI) as parameters of vascular endothelial function and atherosclerotic damage, respectively. Patients were divided into two groups based on the median of serum EPA level: high EPA group and low EPA group. Parameters on vascular inflammation, endothelial function and atherosclerotic damage were compared between the two groups using unpaired t-test, and were analyzed to assess the correlation with the EPA/AA ratio using Pearson's correlation coefficient.
Serum EPA ranged from 29.9 to 145.3 g/mL in all patients, and its median was 72.0 g/mL. No significant differences were observed in hs-CRP and CAVI between the two groups. The PTX3 and IL-1 were significant lower, and the FMD was significantly higher in the high EPA group than in the low EPA group (P<0.01, P<0.05 and P<0.05, respectively). The PTX3 was negatively correlated, and the FMD was positively correlated with the EPA/AA ratio (r=0.549, P<0.05, and r=0.476, P<0.05, respectively).
In conclusion, higher serum EPA improved the vascular endothelial dysfunction via its anti-inflammatory effect in Japanese HD patients.
- © 2011 by American Heart Association, Inc.