Abstract 10067: Low-Density Lipoprotein Particle Number (LDL-P) Distribution in Type 2 Diabetes Who Have Achieved Low Concentrations of Non-HDL Cholesterol (non-HDL-C <80 mg/dL)
Background: Many patients with diabetes have relatively normal levels of LDL cholesterol (LDL-C) yet have increased numbers of other atherogenic lipoproteins. Differences in lipoprotein subclasses with type 2 diabetes (T2DM) who have achieved very low levels of non-HDL-C (less than 80 mg/dL) or LDL-C (Less than 50 mg/dL) have not been extensively examined.
Objective: The aim of this study was to assess variations in lipids, lipoprotein particle concentration in diabetic patients.
Methods: Data were selected from a large single laboratory database. Cases were patients with a T2DM diagnosis code. Lipoprotein particle concentrations were analyzed by nuclear magnetic resonance (NMR) spectroscopy. Lipids were measured at a central laboratory certified for lipid analysis by the Standardization Program of the Centers for Disease Control.
Results: Among the 1,970 patients with T2DM, the mean age was 60.62 for males and 63.22 for females (51.2% male). At LDL-C concentrations of less than 50 mg/dL (triglyceride less than 150 mg/dL and high-density lipoprotein cholesterol (HDL-C) greater than 40 mg/dL), 16% had LDL-P concentration distributions less than 500 nmol/L, 70% were between 500 to 1000 nmol/L, and 14% greater than 1001 nmol/L. At non-HDL-C concentrations of less than 80 mg/dL, 8% had LDL-P concentration less than 500 nmol/L, 67% were between 500 to 1000 nmol/L, and 25% greater than 1001 nmol/L.
Conclusion: Despite attainment of LDL cholesterol goals less than 50 mg/dL or non-HDL-C less than 80 mg/dL, these patients retained considerable residual coronary heart disease risk, with majority of them having LDL-P concentrations greater than 500 nmol/L.
- © 2011 by American Heart Association, Inc.