Abstract 9444: Impaired Peroneal Nerve Function is Associated With Adverse Calf Muscle Characteristics and Functional Impairment in Peripheral Arterial Disease
Background: Previous study shows that severe lower extremity ischemia is associated with impaired peroneal nerve function. We studied associations of lower extremity peroneal nerve function with calf muscle characteristics and functional impairment among men and women with peripheral arterial disease (PAD).
Methods: 413 men and women with PAD (ABI<0.90) in the Walking and Leg Circulation Study (WALCS) II cohort underwent measurement of peroneal nerve conduction velocity (NCV). Functional performance was assessed with the 6 minute walk test. Calf muscle area and percentage fat were measured with computed tomography at 66.67% of the distance between the medial malleolus and top of the tibia.
Results: After adjustment for age, sex, race, ABI, body mass index (BMI), smoking, alcohol consumption, leg symptoms, comorbidities, physical activity, and leg revascularization, reduced peroneal NCV was associated with lower calf muscle area in both non-diabetic and diabetic PAD participants (Table). Poorer peroneal NCV was also associated with poorer six-minute walk performance in non-diabetic and diabetic PAD participants (Table). Associations between peroneal NCV and six-minute walk performance were strongly attenuated after additional adjustment for calf muscle characteristics in both diabetic and non-diabetic PAD participants (Non-diabetic: 1st quartile − 1014.9 ft, 4th quartile − 1211.9 ft, p-trend=0.036; Diabetic: 1st quartile 906.9 ft, 4th quartile − 1060.2 ft, p-trend=0.043).
Conclusions: Reduced peroneal NCV is associated with poorer six minute walk performance in men and women with PAD. These associations may be mediated by adverse calf muscle characteristics.
- © 2010 by American Heart Association, Inc.