Abstract 9258: Metabolic Syndrome is Associated with Reduced Myocardial Function Assessed by Speckle Tracking Echocardiography: The Multi-Ethnic Study of Atherosclerosis
Introduction: Metabolic Syndrome (MeSy) is a cluster of atherogenic risk factors associated with increased cardiovascular morbidity and mortality risk. There is a high prevalence of subclinical cardiovascular disease in subjects with MeSy. Speckle Tracking Echocardiography (STE) is a new non-invasive methods for the assessment of myocardial strain. We assessed the hypothesis that MeSy is associated with subclinical myocardial dysfunction in asymptomatic individuals that may be detected by STE.
Methods: MeSy was defined according to the modified NCEP ATPIII criteria. We analyzed participants in the MESA study who underwent both STE and MRI tagging (reference method), and who had been evaluated for all MeSy components. Multivariate linear regression was used to evaluate the relationship between STE left ventricular (LV) circumferential strain (Ecc) and MeSy status adjusted for age, gender, ethnicity, LV ejection fraction (LVEF), LV mass index (LVMI), creatinine, and smoking (Model 1). In model 2, ECC by MRI was used as the dependent variable replacing strain determined by STE.
Results: Of 133 subjects (women: 63%, age: 65±8 yr), MeSy was present in 41 (31%). Presence of MeSy was associated with reduced left ventricular circumferential strain by STE (Ecc= −16.6±3.5 vs −18.5±3.7) and by MRI (Ecc= −15.8±3.4 vs −17.6±2.3) in univariate analysis (p<0.01 for both). LVEF and LVMI were normal and similar, independently of MeSy status. In multivariate analysis, only Ecc by STE (model 1) and by MRI (model 2) was associated with the presence of MeSy (Table). Ecc by STE was significantly correlated with MRI determined Ecc (p<0.001).
Conclusion: Left ventricular circumferential strain evaluated by STE and MRI tagging is reduced in asymptomatic subjects with metabolic syndrome and normal LV ejection fraction and LV mass index. This observation indicates a relationship between metabolic syndrome and subclinical cardiovascular disease in asymptomatic individuals.
- © 2010 by American Heart Association, Inc.