Abstract 9193: Clinical Characteristics and Outcomes of Centenarians with Acute Myocardial Infarction
Introduction: The number of persons living beyond the age of 100 is increasing. Coronary artery disease remains an important cause of morbidity and mortality in this age group.
Methods: We used the statewide Myocardial Infarction Data Acquisition System (MIDAS) including all admissions for myocardial infarction (MI) in New Jersey to study the occurrence, characteristics, and outcomes of first MIs in patients aged 100–109 years (n=196).
Results: The frequency of MI among centenarians increased from 12 per year in 1995 to 29 in 2004. Centenarians were more likely to be women (84%) compared to 35% of MI patients in a younger cohort, aged 60-69 (p<0.0001). The racial distribution was similar in the two groups with whites comprising 82%. Centenarians were more likely to have anemia (27% vs 10%, p<0.0001), left ventricular dysfunction (26% vs 16%, p<0.0001), renal disease (13% vs 6%, p<0.0001), and cerebrovascular disease (7% vs 4%, p=0.01), but were less likely to have diabetes (9.7% vs 32.4%, p<0.0001) and arrhythmias (17% vs 20%, p<0.0001). They had five times higher in-hospital mortality (31.6% vs 6.3%, p<0.0001) and one-year mortality (70.4% vs 13.3%, p<.0001) than the younger age group. One-year mortality rate of centenarians who sustained an MI was four times higher compared to centenarians who did not have an MI as calculated using the NJ 2000 census (mortality rate of 17.7%).
Conclusions: The number of centenarians who suffer acute MI is increasing. Acute MI carries a grave prognosis (70% one-year case fatality) in this age group.
- © 2010 by American Heart Association, Inc.