Abstract 9140: Application of 4-Dimensional Echocardiography in the Evaluation of Right Ventricular Adaptation to Anemia in Fetal Sheep
Background: The right ventricle (RV) is the dominant ventricle in normal fetal circulation. We studied the use of 4-dimensional (4D) echocardiography combined with QLab (Philips) and a new TomTec method to evaluate RV function in normal and anemic twin sheep fetuses.
Methods: Chronic anemia was developed in one each of 10 sets of fetal twin lambs (gestational age 125–127d) by removing 30–120 ml of blood and replacing it with isotonic saline for 6–7 days of bleeding; the twins were studied on day 8 or 9 using a Philips iE33 system. Full volumes were acquired with EKG gating using implanted leads and RV volumes were processed with QLab and a new program from TomTec designed specifically for RV measurement. RV volumes, stroke volumes (SV), and ejection fractions (EF) measured using the 2 programs were compared and the EF and SV of normal and anemic fetal lambs were also correlated with hemoglobin (mean 11.52 ± 1.62, normal; 4.61 ± 1.15 g/dl, anemic; p<0.001).
Results: RV volumes from 8 normal and 8 anemic fetal twins were suitable for analysis. There were no significant RV volume, EF, and SV differences between QLab and the TomTec program. The data showed adaptation of the anemic fetuses to RV volume loading, with an increase in EF and SV compared to normal fetuses (Table). Better correlations were found between EF and SV by using the TomTec method.
Conclusions: 4D echo provided estimates of RV volume and function in adaptation to volume loading.
- © 2010 by American Heart Association, Inc.