Abstract 8983: Three-Year Clinical Outcomes of the OLIVUS (Impact of Olmesartan on Progression of Coronary Atherosclerosis; Evaluation by Intravascular Ultrasound) Trial
Background: The OLIVUS trial, using volumetric IVUS, reported a positive role in achieving a potentially lower rate of coronary atheroma progression through the administration of Olmesartan, an angiotension-II receptor blocking agent (ARB), for stable angina pectoris (SAP) patients requiring percutaneous coronary intervention (PCI). However, the benefits between ARB administration on long-term clinical outcomes and serial atheroma changes by IVUS remain unclear. Thus, we examined the 3-year clinical outcomes from OLIVUS according to treatment strategy with Olmesartan.
Methods: In the OLIVUS trial, serial volumetric IVUS examinations (baseline and 14 months) were performed in 247 patients with SAP. When these patients underwent PCI for culprit lesions, IVUS was performed in their non-culprit vessels. Patients were randomly assigned to receive 20–40mg of Olmesartan or control, and treated with a combination of β-blockers, calcium channel blockers, diuretics, nitrates, glycemic control agents and/or statins per physician's guidance. Three-year clinical outcomes and annual progression rate of atherosclerosis, assessed by serial volumetric IVUS (mean lengths; 43mm), were compared with major adverse cardio- and cerebrovascular events (MACCE).
Results: Cumulative event-free survival was significantly higher in the Olmesartan group than in the control group (p=0.03; log-rank test). By adjusting for validated prognosticators, Olmesartan administration was identified as a good predictor of MACCE (Hazard Ratio; 0.76, 95%CI 0.45–0.89; p=0.041). On the other hand, patients with adverse events (n=17) had larger annual atheroma progression than the rest of the population (23.8±18.7% vs. 2.1±13.8%, P<0.001).
Conclusions: Olmesartan therapy appears to confer improved long-term clinical outcomes. Atheroma volume changes, assessed by IVUS, seem to be a reliable surrogate for future major adverse cardio- and cerebrovascular events in this study cohort.
- © 2010 by American Heart Association, Inc.