Abstract 8912: Exposure - Response Relationship between Percutaneous Coronary Intervention-Related Blood Loss and Adverse Events, Results from the Strategic Transcatheter Evaluation of New Therapies (STENT) Group
Background: We aimed to demonstrate the exposure - response relationship between percutaneous coronary intervention (PCI)-related blood loss (PBL) and post-PCI adverse outcomes.
Methods: We utilized a subset of the STENT registry who underwent PCI during May 2003 – June 2006. PBL was defined as the difference between baseline hemoglobin and post-PCI lowest hemoglobin levels during the index hospitalization. The independent variables in multivariate Cox proportional hazard model (Table) were chosen based upon the univariate analysis results.
Results: Characteristics of a total population N=19893 were mean age 63.4±11.9 years, female gender 6667 (33.6%), diabetes 6481 (32.6%), mean PBL 1.3±1.4 g/dL and use of drug eluting stents 16092 (80.9%). Adverse events at 3months included all cause death 423 (2.1%), cardiac death 340 (1.7%), myocardial infarction (MI) 431 (2.2%) and stent thrombosis (ST) 136 (0.7%). The relationships between risk of the adverse events and PBL are demonstrated in Table and Figures. When PBL was used as a continuous variable in the multivariate model, hazard ratios (HR) of PBL for the adverse events were 1.3 (95CI:1.3–1.4) for all cause death, 1.4 (1.3–1.5) for cardiac death, 1.2 (1.1–1.3) for MI and 1.3 (1.2–1.5) for ST.
Conclusions: The study demonstrated the significant exposure - response relationship between PBL and post-PCI adverse events including ST.
- © 2010 by American Heart Association, Inc.