Abstract 8865: Correlation between High Density Lipoprotein-Cholesterol and Remodeling Index in Patients with Coronary Artery Disease: An Intravascular Ultrasound Study
Background: Serum level of HDL-cholesterol is associated with risk of coronary artery disease. We correlated the serum level of cholesterol with coronary artery remodeling index of patients with coronary artery disease.
Hypothesis: We evaluated the hypothesis that serum level of HDL-cholesterol was correlated with coronary remodeling index.
Methods: A total of 120 patients (diabetic, n=57) with de novo lesions located in native coronary artery were studied. Remodeling index was based on intravascular ultrasound (IVUS) interrogation of the lesions using the static approach, and was defined as external elastic membrane (EEM) area at lesion/average EEM area at proximal and distal reference segments.
Results: Among the study patients, 76 (63.3%) were on statin therapy during the IVUS exmination. The average levels of total cholesterol was 194.3 ± 49.0 mg/dL, HDL-cholesterol 41.5 ± 10.7 mg/dL, LDL-cholesterol 120.2 ± 41.2 mg/dL, and triglyceride 61.4 +22.7 mg/dL. The average remodeling index was 0.9 (SD: 0.2). The remodeling index was not associated with any of the demographic and coronary risk factors. Stable angina was associated with a low remodeling index. Remodeling index correlated with white blood cell count and HDL-cholesterol, but not with total cholesterol, LDL-cholesterol and triglyceride. In the multiple linear regression analysis, HDL-cholesterol and procedure indication were the only 2 significant predictors of remodeling index. An increase of 1 mg/dL of HDL-cholesterol resulted in a decrease of 0.003 (95% CI: 0.0001, 0.007; p = 0.046) in remodeling index, after adjusting for procedural indications. When stratified according to diabetic status, the negative correlation persisted in non-diabetic (p = 0.023), but not in diabetic, patients (p = 0.707).
Conclusions: We found a negative correlation between HDL-cholesterol level and remodeling index. Diabetic status may have an influence on the observed relationship.
- © 2010 by American Heart Association, Inc.