Abstract 81: Amplitude Spectrum Area Predicts the Success of Defibrillation on Rats During Cardiopulmonary Resuscitation
Amplitude spectrum area (AMSA) has been used for predicting the success of defibrillation during CPR. However, the efficacy of AMSA on predicting the success of defibrillation on small animals remains controversial. In this study, we investigated whether a certain threshold of AMSA could predict the outcome of defibrillation in a rat CPR model. We hypothesized that the use of AMSA on small animals may also predict the success of defibrillation. Ventricular fibrillation (VF) was induced in 54 male rats, weighing between 450–550g, CPR was started after 8 minutes of untreated VF. Precordial compression was adjusted to achieve coronary perfusion pressure at 24±2 mm Hg. Defibrillation was attempted after 8 minutes of CPR. The AMSA value at 5 seconds before the electrical shock was analyzed. The AMSA value of successful defibrillation was significantly higher than in the failed defibrillation (15.62±3.82 mV·Hz vs 10.00±3.11 mV·Hz, P <0.001). The sensitivity of successful defibrillation of over 12.00 mV·Hz was 0.80. We concluded that the AMSA could predict the success of defibrillation on rats during CPR.
- © 2010 by American Heart Association, Inc.