Redox Metabolism and Cardiovascular Disease: A Translational Research Journey
Life in an oxidizing environment requires efficient oxygen utilization and effective elimination of its metabolic byproducts, reactive oxygen species (ROS). Over the past several years, our group has focused on understanding the factors that govern the utilization of oxygen and the metabolism of ROS in the cardiovascular system in health and disease. We have studied key regulators of oxygen consumption and mitochondrial function, as well as key determinants of redox regulation in vascular cells. We found that these molecules form a complex metabolic network that governs cellular redox state. Perturbations in this metabolic network can lead to changes in cell signaling and, in the extreme, the development of pathophenotypes underlying common cardiovascular diseases. Specific examples from basic and clinical studies that support these conclusions will be discussed. These observations highlight the importance of translational research in understanding fundamental cardiovascular (patho)biology.
- © 2010 by American Heart Association, Inc.