Abstract 293: Effects of Atorvastatin to Negatively Influence Mortality on Endotoxin-Induced Shock in Rat Models
Objective: HMG-CoA reductase inhibitors, also known as Statins, have been commercially available for some time with its known effects to lower serum cholesterol levels. Although this agent is most often administered to patients with hypercholesterolemia, its anti-inflammatory effect have been noted in recent days. The aim of this present study is to evaluate the efficacy of atorvastatin on endotoxin-induced shock in rat models.
Methods: Twenty-six male Sprague-Dawley rats were randomly assigned to either of the following two groups: control group, no medication given; and treatment group, oral administration of atorvastatin (12mg/kg/day) for five days. After then, All rats were anesthetized with i.p. pentobarbital and septic shock was induced by intravenous administration of lipopolysaccharide(LPS, 10 mg/kg in distilled water). Hemodynamic recordings, arterial blood gas analyses, and plasma cytokine concentration measurements were performed on an hourly basis.
Results: A significant difference in mortality rates between control group and treatment group was noted at 15% and 57%, respectively, at 8 h after LPS injection(P<0.05). Accordingly, the treatment group saw a considerable decline in arterial blood pressure and heart rate measurements far greater than the control group(P<0.05). In addition, the treatment group experienced a considerable rise in the levels of base deficit and serum lactate concentrations, compared with the treatment group. Serum glucose levels showed a similar trend with the control group providing greater values than the treatment group(P<0.05).
Conclusions: The present study strongly indicates that oral administration of atorvastatin may be disadvantageous in the prognosis of endotoxin-induced shock, suggestive of its potential to exacerbate mortality. Further studies are warranted to prove its detrimental effect in human patients.
- © 2010 by American Heart Association, Inc.