Abstract 282: Anemia, High LDH, Hyperglycemia, and Low pH on Admission Are Associated With Poor Neurological Outcome in Out-of-Hospital Cardiac Arrest Patients Treated With Hypothermia Therapy From Multicenter Hypothermia Registry in Japan: J-PULSE-Hypo Registry
Background: Although mild hypothermia (MH) has neurological benefits for patients with return of spontaneous circulation (ROSC) after out-of-hospital ventricular fibrillation cardiac arrest, there are limited data about predictors of good neurological outcome in these patients.
Method: Five years (2005–2009) data were available for 452 patients treated with MH in the multicenter registry in Japan (J-Pulse-Hypo). We included 389 patients with initial blood examination and atrial gas sampling. We examined the relationship between initial blood examination data and neurological outcome. Primary end point of this study was favorable neurologic outcome (cerebral performance category (CPC) 1 and 2) rate at 30 days.
Result: According to neurologic outcome at 30 days, we divided all cases into two groups: the favorable outcome group (n=221) and the unfavorable outcome group (n=168). Favorable outcome rate at 30 days was 56.8%. By the multiple logistic regression analysis, age, witness of cardiac arrest, ROSC before admission, hematocrit (HCT), lactate dehydrogenase (LDH), glucose (BS), and pH were revealed as the independent predictors of 30 days favorable outcome. Cutoff values of age, HCT, LDH, BS and pH were obtained by receiver operating characteristic (ROC) curve (shown in Table).
Conclusion: Anemia, high LDH, hyperglycemia, and low pH on admission were significantly associated with poor neurological outcome even among patients treated with hypothermia therapy.
- © 2010 by American Heart Association, Inc.