Abstract 269: Extracorporeal Cardiopulmonary Resuscitation Can Bring a Better Outcome of Out-of-Hospital Cardiac Arrest With Shockable Rhythm Than Conventional CPR: An Interim Report From “Study of Advanced Life Support for Ventricular Fibrillation With Extracorporeal Circulation in Japan “(SAVE-J) Study Group
Background: An objective of this study is to examine the efficacy of extracorporeal cardiopulmonary resuscitation (ECPR) for patients in out-of hospital cardiac arrest (OHCA) with shockable rhythm (ventricular fibrillation (VF) or pulseless ventricular tachycardia (VT)).
Method: Multicenter non-randomized prospective cohort study was conducted. Hypothesis is that the outcome of OHCA with shockable rhythm is similar between ECPR and conventional CPR. During from Sep. 2009 to Mar. 2010, 50 tertiary emergency hospitals were participated in this study. Patient inclusion criteria were 1) VF or VT on scene, 2) cardiac arrest on arrival at hospital, 3) within 45 minutes from a call to an arrival of hospital, and 4) non-ROSC by conventional CPR during 15 minutes after an arrival at hospital. Exclusion criteria are 1) age: 75 yr, 2) poor activities of daily livings, 3) non-cardiac verified cardiac arrest, and 4) hypothermia. According to the inclusion criteria, ECPR was adopted for OHCA in 27 hospitals (ECPR group) and conventional CPR was planned in 23 hospitals (non-ECPR group). We compare ECPR group and non-ECPR group with the proportion of patients with favorable outcome (CPC1 or 2) assessed with the Glasgow-Pittsburgh Cerebral Performance and Overall Performance Categories at 1 month.
Results: Intention-to-treat analysis was performed. One hundred and three patients of ECPR group and 67 patients of non-PCPS group were enrolled in this study. The favorable outcome rate in ECPR group was statistically higher than the rate in non-ECPR group (15.9% VS 0.0% p<0.01).
Conclusions: In an interim report from SAVEJ, ECPR can bring a better outcome of out-of hospital cardiac arrest with shockable rhythm than conventional CPR.
- © 2010 by American Heart Association, Inc.