Abstract 23153: Statins and Risk of Cancer: A Retrospective Cohort Analysis of 45,857 Matched Pairs From an Electronic Medical Records Database of 11 Million Adult Americans
Context: Statins are widely prescribed drugs in the United States for management of dyslipidemia, atherosclerosis, and cardiovascular event risk reduction. Unsettled scientific debate about the association of statins with cancer continues, with high profile studies showing conflicting results.
Objective: To determine whether cancer can be attributed to statin use among a general population of older adults in the United States with at least three years of follow-up.
Design and Patients: Retrospective cohort analysis of incidence of cancer in older adults who have and who have not used statins. More than 11 million analyzable patient records from January 1990 through February 2009 were drawn from the GE Centricity electronic medical records database. Propensity matching found pairs of patients receiving and not receiving statins who shared similar propensities for statin use based on matching variables.
Results: Propensity score methods matched 45,857 comparison pairs of statin vs. non-statin patients. Before matching, cancer occurred in 23,906 of 203,763 (11.7%) statin users, and in 17,457 of 159,004 (11.0%) non-statin users. After matching, incidence of cancer in statin patients fell to 11.37% vs. 11.11% in matched non-statin patients. Pairs were followed for an average of eight years. Multivariate-matched Cox regression analysis showed a non-significant hazard ratio of 1.04 (95% CI = 0.99, 1.09). Kaplan Meier curves for diagnosis of any cancer up to ten years also showed no difference for statin and non-statin users.
Conclusion: This analysis of nearly 46,000 propensity-matched pairs demonstrated no statistically significant increased risk of cancer associated with statins.
- © 2010 by American Heart Association, Inc.