Abstract 21508: Hepatic Steatosis, Obesity and the Metabolic Syndrome Are Independently and Additively Associated With Increased Systemic Inflammation
Background: Hepatic steatosis, obesity, and the metabolic syndrome often coexist, and each have been associated with increased cardiovascular risk. Systemic inflammation may be part of the mechanism underlying these associations.
Hypothesis: We assessed the hypothesis that hepatic steatosis (HS), obesity, and the metabolic syndrome (MS) are independently and collectively associated with an increased odds of elevated high-sensitivity CRP (hs-CRP) levels.
Methods: We evaluated individuals free of clinical cardiovascular disease who underwent clinical evaluations at the Preventive Medical Center of Albert Einstein Hospital (Sao Paulo, Brazil) between 12/2004 and 12/2006. Individuals with a prior history of systemic inflammatory illnesses or liver disease, or those reporting ≥ 20 g alcohol use per day were excluded. HS was diagnosed after a 6-hour fast using an ACUSON XP-10 ultrasound device and was identified by the presence of an ultrasonographic pattern of a bright liver, with evident contrast between hepatic and renal parenchyma. Obesity was defined as a body mass index of ≥ 30 kg/m2, and MS was defined by NHLBI criteria. The cutpoint of ≥ 3 mg/L was used to define “high” hs-CRP. Multivariate robust logistic regression was used to assess the independent and collective associations of HS, obesity, and MS with high hs-CRP.
Results: Our study population consisted of 2,388 individuals (44±9 years, 79% male). HS was detected in 32% of participants, 23% met criteria for MS, and 17% of individuals were obese (mean BMI 26±4 kg/m2). After multivariate regression, HS (OR 2.07; 95% CI: 1.68-2.56), obesity (OR 3.00; 95% CI: 2.39-3.80), and MS (2.39; 95% CI: 1.88-3.04) were all independently associated with high hs-CRP. Combinations of these factors were associated with an additive increase in the odds of high hs-CRP (Table).
Conclusion: Hepatic steatosis, obesity, and the metabolic syndrome are independently and additively associated with increased odds of high hs-CRP levels.
- © 2010 by American Heart Association, Inc.