Abstract 21091: Consistency of 1-yr vs. 3-yr Changes in Plasma HDL-Cholesterol Levels in Response to a Lifestyle Modification Program in Viscerally Obese Dyslipidemic Men.
Introduction: Endurance exercise training and weight loss have favourable effects on the plasma lipoprotein-lipid profile including HDL-cholesterol (C) levels. However, numerous studies that have reported the effects of exercise training on HDL-C have been rather short term.
Objectives: 1- To test whether changes in HDL-C levels observed after 1 yr on a healthy eating - physical activity/endurance exercise program would be maintained over two additional yrs on such program and 2- whether 1-yr changes in HDL-C levels would be predictive of their long term (3 yrs) responses.
Methods: Visceral adiposity was assessed by computed tomography and a complete fasting plasma cardiometabolic risk profile was obtained at baseline and after 1 and 3 yrs on a lifestyle modification program in 89 viscerally obese dyslipidemic men aged 30 to 65 yrs without diabetes. Results: Plasma HDL-C levels increased by 14% (p<0.0001) after 1 yr and remained elevated until completion of the study (3 yrs) (Δ=+13%, p<0.0001). One-yr changes in HDL-C levels were also correlated with their 3-yr changes (r= 0.55, p<0.0001). One-yr and 3-yr changes in other parameters such as triglycerides (r=0.59, p<0.0001.), LDL-C (r= 0.48, p<0.0001) and the C/HDL-C ratio (r= 0.58, p<0.0001) were also correlated. However, the strongest correlation between 1-yr and 3-yr changes was observed for fasting insulin levels (r=0.82, p<0.0001). One-yr changes in inflammatory markers were weakly but significantly correlated with 3-yr changes (adiponectin: r= 0.25, p=0.02, IL-6: r= 0.22, p=0.04, CRP: r= 0.41, p<0.0001 and TNF-α: r= 0.32, p=0.004). Finally, men were classified into two groups: men who decreased their HDL-C levels between yr 1 and yr 3 vs. men who did not change or increased their HDL-C levels over this period. Compared to men who decreased their HDL-C levels between yr 1 and yr 3, men who maintained/increased their HDL-C levels showed a further reduction in fasting insulin levels (Δ=-14%, p=0.001) and an increase in adiponectin levels (Δ=+55%, p<0.0001).
Conclusion: These results indicate that in response to a 3-yr lifestyle modification program in viscerally obese men, 1-yr changes in HDL-C are maintained over two additional yrs and 1-yr HDL-C changes are predictive of their long term (3 yrs) response.
- © 2010 by American Heart Association, Inc.