Abstract 20999: Determinants of Reaching Guideline-Recommended LDL-Cholesterol Targets in Secondary Prevention in Europe and Canada: Results of the Dyslipidemia International Study
Background: The majority of patients with dyslipidemia are currently treated with a statin. However, many patients do not achieve recommended lipid targets, and persistent lipid abnormalities will continue to contribute to cardiovascular risk in statin-treated patients.
Methods: Between June 2008 and February 2009, 2,987 primary care physicians, cardiologists, endocrinologists and internists in 11 European countries and Canada enrolled 22,063 consecutive statin-treated outpatients into DYSIS (Dyslipidemia International Study) to assess the prevalence of dyslipidemia (lipid values were recorded when on chronic statin treatment). ESC recommendations were used to classify patient's risk and define the LDL-C goal. We examined predictors of LDL-C goal achievement in clinical practice.
Results: Overall nearly half of all patients had LDL-cholesterol not at goal (48.5%).
Conclusion: Patients with already known ischemic heart disease, cerebrovascular disease or diabetes were more likely to achieve the recommended LDL-C goal. Treatment with higher statin dosages, with ezetemibe and treatment by specialists (internists, cardiologists, diabetologists) were independent predictors of better LDL-C goal achievement in clinical practice.
- © 2010 by American Heart Association, Inc.