Abstract 20960: Doubled 5-Year-Mortality in Diabetics with Stable Angina in Clinical Practice: Results of the STAR-Registry
Background: Diabetes is a major risk factor for the development of coronary artery disease and a predictor of an impaired outcome in acute coronary syndromes. Little is known about treatment and long-term outcome of diabetics with stable angina (AP) in clinical practice in Germany.
Methods: Between Sept 2001 and March 2003, a total of 2,002 consecutive patients with AP and first angiographic diagnosis of coronary artery disease (CAD) were enrolled in the STAR-Registry (50 centres) and followed for five years. In 1,991 patients, information about diabetes was available. We examined the impact of diabetes on treatment of stable angina and five-year-outcome.
Results: Diabetes was known in 526 patients (26.4 %). Diabetics more often were female; more often had prior MI, prior stroke as well as hypertension. They less often had preserved left ventricular function as compared to non-diabetics. Diabetics underwent PCI less often, but CABG more often within the course of the disease. There were no differences in the medical treatment at 5 years between diabetics and non-diabetics. At 5 years after the first angiographic diagnosis of CAD, diabetics had a significantly higher mortality. After correcting for differences in baseline characteristics and for interventional and long-term medical treatment using a stepwise logistic regression analysis, diabetes was associated with a more than 1.7-fold increased 5-year-morality (HR 1.71; 95% CI 1.32–2.20).
Conclusions: In clinical practice in Germany, Diabetics with stable angina have a nearly doubled 5-year-mortality as compared to non-diabetics.
- © 2010 by American Heart Association, Inc.