Abstract 20935: Obesity is Independently Associated With Vascular Inflammation in Low-Risk Individuals
Background: Inflammation is central to both obesity and atherosclerosis. Since vascular 18-fluorodeoxyglucose (FDG) uptake correlates with vascular inflammation, we tested the hypothesis that increased adiposity, measured as body mass index (BMI) is associated with increased FDG uptake within the aortic wall.
Methods: Fifty patients without coronary artery disease (CAD) or diabetes (mean age ± sd: 67±12 years, 53% males) underwent FDG-PET-CT imaging 1–3 hours after FDG administration. Vascular inflammation was measured as FDG uptake within the wall of the ascending aorta. A target to background ratio (TBR) of aortic wall to blood FDG uptake was calculated and subsequently compared to the subjects' BMI.
Results: Inflammation, measured by aortic FDG uptake (TBR) is increased with increasing BMI (1.41± 0.36 for BMI≤ 24.99, 1.89±0.44 for BMI = 25–29.99, and 2.0±0.52 for BMI ≥ 30, p<0.001 for linear trend). Additionally, TBR is positively correlated to BMI (r= 0.57, p<0.001), with BMI remaining an independent predictor of FDG uptake after adjusting for age, gender, hypertension, smoking, statin therapy, and hyperlipidemia (B[95% CI]: 0.03[0.001–0.05], p=0.04). Further, in a subset of 21 lower risk, statin-naive patients without CAD, diabetes, metabolic syndrome, or > 1 modifiable cardiac risk factors (67±14 years old, 57% males), BMI remained well-correlated with FDG uptake (r= 0.54, p=0.01) and remained an independent predictor of vascular FDG uptake after adjusting for gender, hypertension, smoking, and hyperlipidemia (B[95% CI]: 0.035[0.007–0.063], p=0.02).
Conclusions: Vascular inflammation assessed by FDG uptake is increased with increasing adiposity. This preliminary data suggests that otherwise low-risk patients with high BMI have increased vascular inflammation.
- © 2010 by American Heart Association, Inc.