Abstract 20824: Aged Garlic Extract Supplemented with B Vitamins, Folic Acid and L-Arginine Reduce the Progression of Adipose Tissue and Coronary Artery Calcium
Background: We recently reported that aged garlic extract supplemented with B vitamins, folic acid and L-arginine (AGE+S) is associated with a favorable improvement in oxidative biomarkers, vascular function, and reduced progression of coronary atherosclerosis. Increased epicardial (EAT), pericardial (PAT), peri-aortic (PaAT) and subcutaneous adipose tissue (SAT) are mediators of metabolic risk, and are associated with the severity of coronary artery calcium (CAC). The current study evaluates the effect of AGE+S on progression of CAC and thoracic adipose tissue.
Methods: Sixty asymptomatic subjects randomized to AGE-S vs. placebo, and underwent non-enhanced computed tomography at baseline and after 12-months of treatment, and their CAC and adipose tissue were measured. EAT, PAT, PaAT and SAT volumes were measured from slice level 10 mm above the ostium of left main coronary artery to the bottom of the heart. EAT wad defined as inside pericardium adipose tissue. PAT was calculated as [PAT=Total thoracic adipose tissue - EAT]. SAT was defined as the volume of fat depot anterior to the sternum and posterior to the vertebra. PaAT was defined as fat depot around the descending aorta. CAC progression was defined as annual increase in CAC>15%.
Results: At baseline, there were no significant differences in cardiovascular risk factors, age, gender, CAC and adipose tissue among cohorts (P>0.05) (Table). From baseline to 12 months, a strong correlation was noted between increase in CAC scores and EAT(r=0.73, p=0.0001), PaAT(r=0.65, p=0.001), PAT(r=0.56, p=0.008) and SAT (r=0.51, p=0.01). At 1 year, CAC progression and increase in EAT, PAT, PaAT and SAT were significantly lower in the AGE+S as compared to the placebo group after adjustment of cardiovascular risk factors and BMI (p<0.05)(Figure).
Conclusion: This study demonstrates that AGE+S significantly reduce the progression of CAC and adipose tissue.
- © 2010 by American Heart Association, Inc.