Abstract 20815: Long-Term Clinical Outcomes in Patients With Renal Insufficiency After Sirolimus-Eluting Stents Implantations: Three-Year Follow-up Results of the j-Cypher Registry
Purpose: We sought to evaluate the impact of baseline renal function on clinical outcomes in sirolimus-eluting stent (SES) recipients in the real-world registry.
Methods: The design of the j-Cypher Registry was multicenter prospective enrollment of consecutive patients who underwent SES implantations from 41 centers in Japan. We reviewed 3-year clinical outcomes of 10 775 patients who underwent SES implantation exclusively and successfully between August 2004 and December 2006. Patients were stratified into 5 groups according to their estimated glomerular filtration rate (eGFR): Group I, eGFR ≥90 ml/min/1.73m2 (normal function); Group II, eGFR <90 and ≥60 ml/min/1.73m2 (mild insufficiency); Group III, eGFR <60 and ≥30 ml/min/1.73m2 (moderate insufficiency); Group IV, eGFR <30 ml/min/1.73m2 and not on hemodialysis (HD) (severe insufficiency); and Group V, renal failure treated with HD.
Results: The baseline characteristics and 3-year clinical outcomes are shown in the table. The target lesion revascularization (TLR) rate of each non-HD group was low and similar regardless of the degree of renal insufficiency, whereas the stent thrombosis rates of HD and severe renal insufficiency group were significantly higher than other groups. By multivariate analysis, Group V and Group IV were strong predictors of cardiac and total death.
Conclusions: The effect of renal insufficiency on PCI results with SES is heterogeneous in each clinical event.
- © 2010 by American Heart Association, Inc.