Abstract 20813: Markers of Osteoregulation and Coronary Artery Calcification in Apparently Healthy High-Risk Families
Background: Osteoregulatory pathways are thought to play a role in the development of coronary artery calcification (CAC) but the contribution of related serum biomarkers remain poorly understood. We thus examined a comprehensive panel of soluble markers of bone mineralization and their relationship to CAC in apparently healthy siblings of persons with premature coronary artery disease (CAD) <60 years of age.
Methods: We screened 553 siblings (mean age 48.8 ± 7.2 years, 63.3% female, 50.3% African American) for traditional coronary artery disease (CAD) risk factors and for levels of serum calcium, ionized calcium, phosphate, parathyroid hormone, 1,25-dihydroxy vitamin D, osteopontin, osteoprotegerin, and matrix GLA protein. Participants underwent ultrafast helical computed tomography to assess CAC. The association of biomarkers with CAC was analyzed using Tobit regression of the CAC log(Agatston score +1).
Results: Detectable CAC was present in 40.9% of subjects. Adjusting for known CAD risk factors, 1,25-dihydroxy vitamin D was strongly and inversely associated with the presence and extent of CAC, and parathyroid hormone was inversely associated with the extent of CAC (Table). No other bone mineralization serum markers were significantly associated with CAC.
Conclusion: Although metabolically active vitamin D has been shown to be inversely associated with CAC in some populations, this is the first study to report strong inverse associations of both metabolically active vitamin D and parathyroid hormone with CAC, independent of known CAD risk factors, in a high risk asymptomatic population of siblings of persons with premature CAD. Further investigation targeting parathyroid hormone and 1,25-dihydroxy vitamin D may improve understanding of the mechanisms of atherogenesis and coronary plaque calcification and may result in novel strategies in the prevention of CAD.
- © 2010 by American Heart Association, Inc.