Abstract 20745: Effect of Reduced Renal Function after Voluntary Kidney Donation on Cardiac Structure and Function and Arterial Stiffness
Background: Although renal impairment is an established risk factor for cardiovascular (CV) disease, there is limited information regarding the effect of reduced renal function after voluntary kidney donation on CV risk. Aims: To evaluate the influence of reduced renal function after voluntary kidney donation on prognostically-significant risk markers of CV structure and function.
Methods: In this study of 40 voluntary kidney donors (VKD) (age 59.7 ± 8.5yrs; 42% men) who had eGFR>75mL/min preceding kidney donation (7.0 ± 4.1yrs prior), we randomly selected age/sex-matched normal controls with eGFR>75ml/min from a large population-based cohort study and clinic-based comparators with stage 3 chronic kidney disease (CKD). Cardiac structure and function was assessed by echocardiography. Central blood pressure and carotid-femoral pulse wave velocity (PWV), an index of arterial stiffness, were estimated by applanation tonometry.
Results: Compared to normal controls, VKD and CKD groups had reduced left ventricular (LV) size (p=0.001); increased LV relative wall thickness (p=0.002); increased left atrial size (p=0.04); increased central pulse pressure (p=0.02); and increased PWV (p=0.03). In multivariable analysis, these associations remained significant after adjusting for clinical risk factors for CV disease (all p<0.05).
Conclusions: Reduced renal function in VKD is associated with altered cardiac structure and increased arterial stiffness. Larger prospective studies are needed to evaluate whether these CV alterations result in adverse clinical outcomes.
- © 2010 by American Heart Association, Inc.