Abstract 20696: The Role of Mannose-Binding Lectin in Atherogenic and Inflammatory Disease in Metabolic Syndrome: A Prospective Weight Reduction Study
Introduction: In subjects with the metabolic syndrome (MetS) endothelial dysfunction is a very consistent finding. Processes leading to endothelial dysfunction and atherosclerosis involve the altered control of subclinical inflammation by innate immune defenses that possibly include mannose-binding lectine (MBL). We investigated the associations of MBL with traits of the MetS and associated markers of early atherogenesis in subjects with fully expressed MetS. Moreover, we studied the alteration in the cluster of the MetS-related factors associated with changes of MBL by means of extreme weight reduction in the same individuals. For comparison, we studied MBL-effects cross-sectionally in lean healthy individuals.
Methods: In a prospective longitudinal study, 120 severly obese subjects with MetS (mean BMI 40±8 kg/m2) plasma MBL concentrations were examined in association with markers of insulin resistance, dyslipidemia, adipokines, and subclinical atherosclerosis before and after marked weight loss (mean weight loss 20±8 kg after 3 months of participation in a standardized weight reduction program), in addition to the study of 30 seemingly healthy lean subjects (BMI 20-25 kg/m2).
Results: In lean subjects, low MBL-levels (<500 μg/mL) were significantly related to benefical MetS traits such as higher HDL-cholesterol levels, higher ApoA2 levels, lower fasting glucose levels, lower triglycerides, and moreover, higher resistin plasma levels. In obese subjects with MetS low MBL levels were even related to insulin resistance markers such as lower free fatty acids and atherosclerosis-markers such as lower oxLDL-levels. Using principal component factor analysis, the changes associated with marked weight reduction revealed high correlations between MBL-levels and atherogenic oxLDL- and ApoB-levels (std. score coefficients [significant if >0.20]: MBL=0.37, oxLDL=0.50, ApoB=0,32) suggesting a role of MBL and weight reduction in early atherogenesis.
Conclusions: Our findings suggest that MBL, which is involved in inflammation and immune system functions, affects metabolic pathways and potentially influences the link between obesity, inflammation, and endothelial function leading to atherosclerosis.
- © 2010 by American Heart Association, Inc.