Abstract 20615: Comparing RFCA versus Medications in Patients With Frequent Premature Ventricular Complexes From RVOT----Result From Prospective Cohort Study
Objectives: The aim of this study was designed to compare the long-term efficacy between radiofrequency catheter ablation and antiarrhythmic drugs in patients with frequent premature ventricular contractions (PVC) from right ventricular outflow tract (RVOT).
Background: Antiarrhythmic agents and catheter ablation are widely used to treat frequent premature ventricular contractions, but their efficacy was not compare.
Methods: Three hundred and eighteen patients with frequent PVC orginated from RVOT were assigned to two treatment group: group 1 received catheter ablation, group 2 received antiarrhythmic agents. The number of PVC and PVC burden were measured by 12-lead Holter at baseline, and 12 Holter examination was repeated at 1, 3, 6 and 12 month after intervention. LVEF was evaulated by transthoracic echocardiogram at baseline and 3, 6 months. The primary endpoint was the recurrence of PVC with the same QRS morphologies compare to that before intervention.
Results: The primary endpoint was reached in 31 patients (19.5%) in group 1, 143 patients (89.9%) in group 2 ( P<0.0001). The Kaplan-Meier survival analysis demonstrated a significant reduction in PVC recurrence in radiofrequency ablation group (P<0.0001, log-rank test) when compared with group 2. The QRS morphology of PVC was main predicting factor of PVC recurrence, the Kaplan-Meier survival analysis also demonstrated a significant reduction of PVC recurrence in patients with QS morphology ( P<0.006, log-rank test) than that in patients with rsr'/rsR' and qR/R/Rs morphology in lead I.
Conclusions: Catheter ablation is more effective than antiarrhythmic agent for preventing PVC recurrence in patients with PVC originated from RVOT.
- © 2010 by American Heart Association, Inc.