Abstract 20540: Long-Term Change in Risk Factor Burden and Coronary Artery Calcification - - The Chicago Healthy Aging Study (CHAS)
Background: Low burden of CVD risk factors (RF) at younger ages is associated with substantially reduced risk for future clinical CVD events. Little information is available regarding associations of long-term changes in RF burden - - from young adulthood to older age - - with subclinical atherosclerosis, as measured by coronary artery calcium (CAC), at older age.
Methods: Using data from CHAS (n=834), we assessed associations of changes in RF burden (hypertension, hypercholesterolemia, obesity, diabetes, cigarette smoking) measured at baseline (1967-73) and follow-up (2007-10) with CAC at follow-up (see Table for definition of RF groups). CAC by multi-detector computed tomography was quantified by Agatston's method.
Results: The study sample (27% women) was baseline ages 25-44 years, free of major ECG abnormalities and MI; mean follow-up age 71. After 39 years, CAC score >0 was observed in 70% of participants who had no RF at both baseline and follow-up (group A) vs. 82% of others (p<0.001). Further, increase in number of RFs from baseline to follow-up, especially among those with ≥1 RF at baseline (group E), was associated with greater likelihood of having any CAC (CAC >0) and advanced CAC (score >100 or >400) (see Table).
Conclusion: These data are among the first to examine the association of long-term changes in RF burden with CAC at older age. Long-term absence of RFs is associated with lowest prevalence of any CAC and advanced CAC, although some CAC was still present in the majority of this group. RF burden in young adulthood and increase of RFs over decades both were associated with substantially increased odds of having advanced CAC at older ages.
- © 2010 by American Heart Association, Inc.