Abstract 20355: Aortic Atherosclerosis and Left Ventricular Structure
Background: We previously reported that aortic atherosclerosis is associated with concentric left ventricular (LV) remodeling. We sought to determine whether this relationship is mediated by associated vascular stiffness.
Methods: 655 (age 59 ± 9 yr; 54% F) Framingham Offspring Cohort examination cycle 7 participants underwent multidetector CT, cardiovascular MRI and tonometry testing. We used multivariable adjusted linear regression models to relate thoracic aortic (TAC) and abdominal aortic (AAC) calcium on MDCT and abdominal aortic plaque (AAP) on CMR to LV wall thickness (LVWT), LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV) and LV mass/volume ratio (LVM/LVEDV) on CMR, in models adjusting for indices of vascular stiffness (carotid femoral pulse wave velocity [CFPWV], central pulse pressure [CPP], mean arterial pressure [MAP]). All models also included age, sex, body mass index, systolic blood pressure, hypertension therapy, diabetes, total/high density lipoprotein cholesterol ratio, lipid-modifying therapy, smoking and estimated glomerular filtration rate as covariates.
Results: There was a continuous increase in LVM/LVEDV with increasing TAC and AAP in multivariable models, that endured after adjusting for any of the vascular stiffness measures (Table). AAP was also associated with increasing LVESV and LVWT after adjusting for vascular stiffness (Table). AAC was not associated with any LV measures.
Conclusion: In this free living cohort, we observed associations of aortic atherosclerosis with LV remodeling that were mostly independent of vascular stiffness. Other mechanisms that may mediate these relations need further elucidation.
- © 2010 by American Heart Association, Inc.