Abstract 20115: Stroke is Associated With Higher Degree of Atrial Fibrosis in Patients With Atrial Fibrillation: Lessons Learned From De-Mri
Background: We sought to assess the degree of atrial fibrosis in patients with atrial fibrillation and correlate it to risk of stroke.
Methods and Results: A total of 387 patients (63.2% male, mean age of 65±12 years old) with AF were included in this study. A history of previous stroke was present in 36 (9.3%) patients (13 male, mean age 64±12 years old). All patients underwent delayed-enhancement MRI (DE-MRI) to quantify left atrial (LA) fibrosis. Based on the amount of fibrosis, patients were staged into 4 groups: Utah I (≤5% LA wall enhancement), Utah II (>5% to ≤20%), Utah III (>20% to ≤35%) and Utah IV (>35%) [Figure 1]. Patients with previous strokes had significantly higher percent LA fibrosis (24.4±12.4% vs. 16.2±9.9%, p<0.01). 4.55% of the patients in Utah I, 6,12% of the patients in Utah II, 15.96% of the patients in Utah III and 19,23% of the patients were identified with a history of stroke. The percentage of patients with a history of previous stroke was significantly higher in Utah III and IV compared to Utah I and II (16.66% vs 5.9%; p=0.002, Figure 2).
Conclusion: Our preliminary results suggest that the amount of LA fibrosis detected by DE-MRI can be used for individual stroke risk stratification in patients with atrial fibrillation.
- © 2010 by American Heart Association, Inc.