Abstract 20077: Relationship Between Serum 25-Hydroxyvitamin D and C- Reactive Protein:Findings From the Continuous National Health and Nutrition Examination Survey 2001-2006.
Objective: Relationship between vitamin D deficiency and increased systemic inflammation is not settled.To study this relationship in adult US population, we examined the association between serum 25- hydroxyvitamin D (25[OH]D) and c-reactive protein (crp) levels, a biomarker of inflammation.
Method: Publically available continuous National Health and Nutrition Examination Survey data for years 2001-2006 was analyzed. Multivariable linear regression models were used to explore relationship between serum 25(OH) D and crp.
Results: In univariate linear regression with spline [single knot at median of 25 (OH)D], we found that crp decreased as 25(OH) D increased (mean crp change = - 0.204 mg/dL per 10 ng/mL change in 25(OH) D, 95% CI - 0.262, - 0.146) till 21 ng/mL. Levels above 21 ng/mL were not associated with a significant change in crp (mean crp change = - 0.0104 mg/dL per 10 ng/mL change in 25(OH) D, 95% CI - 0.0481, 0.0272). The inverse relationship between 25(OH) D below its median and crp remain significant (mean crp change = - 0.07 mg/dL per 10 ng/mL change in 25(OH) D, 95% CI -0.12, -0.01) in multivariate linear regression analysis. Once adjusted for demographics, obesity, blood pressure, glucose and renal function, a positive relationship between 25(OH) D above its median and crp (mean log crp change = 0.0821 mg/dL per 10 ng/mL change in 25(OH) D, 95% CI 0.05, 0.12) was observed.
Conclusions: In healthy adults, crp decreased as 25(OH) D goes up to 21 ng/mL. Above 21 ng/mL, 25(OH) D is probably associated with worsening inflammation as measured by significant rise in serum crp. Repletion with 25(OH) D seems beneficial in reducing inflammation among individuals natively low in 25(OH) D.
- © 2010 by American Heart Association, Inc.