Abstract 20070: Validation of New Score System for Left Atrium Thrombus Risk Prediction in Atrial Fibrillation.
Introduction: SPACED (Stroke, Permanent AF, AF duration, CHF, spontaneous Echo contrast and Diabetes) is a novel risk assessment tool for the prediction of left atrial appendage thrombus (LAAT) derived from 487 patients with non-valvular atrial fibrillation (NVAF). The purpose of this study was to prospectively validate this new tool, particularly among older patients.
Methods: 387 NVAF patients (age (63.4±14.8; 70.5%male) underwent TEE screening for LAAT including 90 patients ≥ 75 years old. Performance characteristics were compared to CHADS2 score system.
Results: LAAT was identified in 33 patients (72.2+14.6; 48.5%). The overall sensitivity and specificity (AUC) for CHADS2 (0.79) and SPACED (0.78) were similar (p=0.7; Figure 1). For patients > 75 years (81+5.4; 63.6%; Figure 2), SPACED (AUC 0.74) was more predictive of LAAT compared to CHADS2 (0.54; p<0.001).
Conclusion: Risk assessment tools for AF help define those individuals most suited for anticoagulant therapy. For elderly patients who are greatest risk for both stroke and bleeding, this novel risk assessment tool may help stratify those individuals who would most benefit from anticoagulant therapy.
- © 2010 by American Heart Association, Inc.