Abstract 19998: Coronary Artery Calcium and Bone Mineral Density Measured Computed Tomography: Impact of Age, Gender and Ethnicity
Background: Osteoporosis and atherosclerosis are major public health problems that often coexist in both genders worldwide. Coronary artery calcium (CAC), an anatomic marker of burden of atherosclerosis, correlates with the presence and extent of coronary artery disease(CAD). The current study investigates the correlation between CAC and thoracic bone mineral density (BMD) measured by computed tomography(CT) in an asymptomatic population.
Methods: Five thousand five hundred and ninety asymptomatic subjects, age 57±12, 69% male, underwent non-enhanced CT and their thoracic BMD and CAC score were measured. The mean bone mineral density[BMD (mg/cc)] of four consecutive thoracic vertebrae was measured starting at the left main coronary slice level using QCT-5000 and N-Vivo softwares(Image analysis, Kentucky). Subjects were divided into individuals without CAC (CAC 0) and those with CAC (CAC:1–100, 101–400 and 400+).
Results: CAC is inversely associated with BMD (r= −0.29, p=0.0001). BMD decreased proportionally with increasing CAC from CAC 0 (178.4±44.4) to CAC 1–100 (169.6±42.3) to CAC 101–400 (155.3±42.4) to CAC 400+ (145.2±44.6)(p=0.0001) in both genders across multi-ethnicity (Figure). After adjustment for risk factors, the relative risk for each standard deviation decrease in BMD was 1.21(95%CI 1.01–1.49, p=0.05) for CAC 1–100, 2.03 (95%CI 1.54–2.66, p=0.0001) for CAC 101–400, and 2.74(95%CI 2.03–3.66, p=0.0001) for CAC 400+ as compared to CAC 0, respectively.
Conclusion: This study provides evidence that lower levels of bone mineral density are associated with the severity of subclinical atherosclerosis measured by CAC independent of risk factors.
- Cardiac CT
- Cardiovascular disease prevention
- Coronary artery disease
- Subclinical atherosclerosis
- © 2010 by American Heart Association, Inc.