Abstract 19876: Hyponatremia Leads to Poor Outcomes in Heart Failure Patients With Preserved Ejection Fraction
Introduction: There is a paucity of literature on the outcomes in heart failure (HF) patients with preserved ejection fraction (HFPEF) and hyponatremia. Hyponatremia is a poor prognostic indicator in systolic HF patients with low ejection fraction. The aim of this study was to assess the mortality and re-admission rates in HFPEF with hyponatremia versus those patients with normal serum sodium (S. Na).
Hypothesis: HFPEF and hyponatremia have poor outcomes when compared to those patients with a normal S. Na.
Methods: This is a retrospective study where records were searched to obtain data over the past ten years. Patients with HFPEF and hyponatremia (n=5,729) were compared to those with HFPEF and normal serum sodium (n=14,579). Patients with EF ≥ 50% were included in the study. S.Na < 135 mEq/L was considered as hyponatremia and levels ≥ 135 – 145 mEq/L were considered as normal. The mortality and re-admission rates for exacerbations of HF in patients with HFPEF and hyponatremia versus those with a normal S. Na were calculated.
Results: The mean EF in both groups was 61 +/− 6%. The mean S. Na in patients with hyponatremia was 132 +/− 2.4 mEq/L and in patients with normal S. Na it was 139 +/− 2.7 mEq/L. Mortality (p < 0.0001) and re-admission rates up to five years were statistically significant for HFPEF with hyponatremia when compared to HFPEF with normal serum sodium (see table 1 and graph below).
Conclusions: Hyponatremia in HFPEF seems to be a poor prognostic indicator of mortality. Prospective and multi-center studies need to be conducted to validate these results.
- © 2010 by American Heart Association, Inc.