Abstract 19850: Circulating Adhesion Molecules and Endothelial Function in Depressed Subjects With Coronary Risk Factors.
Background: Although several studies have shown an association between depression and increased morbidity and mortality for ischemic heart disease, the underlying mechanisms are unclear. The aim of this study was to investigate the relationship between molecular markers of atherosclerosis, endothelial dysfunction, and depression in patients free of coronary heart disease (CHD) with increased CHD risk.
Methods: Depression status (Beck Depression Inventory, BDI), selected CHD risk factors, ICAM1 and indices of endothelial function (flow-mediated dilation, FMD) were evaluated in 415 subjects free of CHD, diabetes mellitus, and other life-threatening conditions, with at least two CHD risk factors among the following: older age, male gender, current smoking, hypertension, and dislipidaemia.
Results: Overall, 51.7% of the participants were males, aged 57.6 ± 8.8 years on average (minimum 30, maximum 70). Almost half were hypertensive, 43.9% were dyslipidemic, 30.4% current smokers, and 23.1% showed a depressive symptomatology (BDI ≥ 10). Logistic regression showed that, as compared with non-depressed individuals and after adjustment for age, gender, and hypertension, depressive subjects were significantly more likely to be smokers, to have higher total cholesterol. In addition, depressed subjects were more likely to have altered ICAM-1 (adjusted odds ratio of 1 ng/mL increase= 1.2; 95% CI: 1.1-1.5) and their FMD was severely impaired (adjusted odds ratio of 1% increase = 0.72; 95% CI: 0.61-0.86).
Conclusion: These data indicate an independent association between depression and impaired endothelial function and plasma levels of ICAM-1 as molecular marker for atherosclerosis and the depression symptoms. These mechanisms promote and/or accelerate the early disease and connect depression and CHD.
- © 2010 by American Heart Association, Inc.