Abstract 19822: Epicardial and Pericardial Adipose Tissue are Correlated with Vascular Stiffness Measured as Pulse Wave Velocity
Background: Epicardial adipose tissue (EAT) has been reported to influence coronary atherogenesis and adverse cardiac events. Aortic stiffness measured as pulse wave velocity (PWV) is an independent risk factor of cardiovascular outcome as well. We evaluated the relationship of EAT(inside the pericardium) and pericardial adipose tissue (PAT, outside the pericardium) measured volumetrically by 64 multidetector computed tomography (MDCT) with PWV.
Methods: This study consists of 106 consecutive subjects (Age: 53±13 yrs, 74% male) who underwent MDCT and PWV. EAT volume (ml) was measured from slice level 10 mm above left main coronary artery ostium to bottom of the heart. PAT was calculated as [Intrathoracic adipose tissue - EAT]. Coronary artery calcium (CAC) was defined as CAC 0, CAC 1–100, CAC 101–400 and CAC 400+. Carotid-radial PWV (mm/s) was measured using SphygmoCor tonometery (Atcor Med., Australia). The significant EAT and PAT was defined as their highest tertile.
Results: There was a modest correlation EAT (r=0.41, p=0.0001) and PAT (r=0.34, p=0.001) with PWV. EAT and PAT increased proportionally with increasing CAC and PWV (Figure). The odd ratio of highest vs. lowest tertile of PWV was 3.03 (95% CI 1.22–7.51, p=0.01) for significant EAT (≥111ml) and 2.34 (95% CI 1.1–4.9, p=0.02) for significant PAT (≥103ml) after adjustment for conventional cardiovascular risk factors.
Conclusions: EAT and PAT are associated with the aortic stiffness measured by PWV independent of age, gender and other cardiovascular risk factors.
- © 2010 by American Heart Association, Inc.