Abstract 19776: Angioscopic Comparison of Arterial Repair Between Biodegradable Polymer-Coated Biolimus A9-Eluting Stent and Durable Polymer-Coated Sirolimus-Eluting Stent in Patients
Background: Biodegradable polymer-coated biolimus A9-eluting stent (BES)(Terumo Corporation, Japan) are expected to show better arterial repair than first-generation DES. Thus, using angioscopy (VecmovaNEO, FiberTech, Japan), we investigated the arterial repair following BES implantation, and compared that with durable polymer-coated sirolimus-eluting stent (SES).
Methods: Angioscopy was performed 9 ± 1 months after 15 BES and 16 SES implanted for de novo lesion in the native coronary artery. Heterogeneity of the neointimal coverage (NIC) as well as the dominant NIC grade was examined. NIC was defined as: grade 0 = fully visible struts; grade 1 = struts bulged into the lumen, but covered; grade 2 = embedded, but translucent struts; grade 3 = invisible struts. NIC was defined heterogeneous when different NIC grades of ≥1 grade were present in the entire stented segment. Thrombi and yellow plaques were also explored.
Results: In-stent late loss (0.06 ± 0.23 vs. 0.07 ± 0.18 mm, P=0.80), and dominant NIC grade (1.5 ± 0.8 vs. 1.3 ± 0.7, P=0.45) were similar in BES and in SES. Within the stents, NIC was more heterogeneous in SES than in BES (Figure). Thrombi were detected in 3 BES and 5 SES (P=0.69). Both stents commonly revealed yellow plaques (80% in BES vs. 69% in SES, P=0.69).
Conclusions: BES showed extremely limited late loss similarly to SES. NIC was strongly inhibited; thrombus adhesion and yellow plaques were similarly observed as in SES, but the NIC with BES was more homogeneous than that with SES. Biodegradable polymer-coated BES may have an advantage in acquiring homogeneous NIC.
- © 2010 by American Heart Association, Inc.