Abstract 19704: Significant Correlation between Primitive Cells in Intracoronary Thrombi in Patients with Myocardial Infarction and Lesion Progression
Background Clinical evidence suggests that intracoronary thrombus formation is associated with a high incidence of late restenosis after successful coronary intervention in patients with myocardial infarction. However, little is known about the mechanism by which intracoronary thrombi play pathological roles.
Methods and Results We analyzed the cellular constituents of 108 thrombi aspirated from coronary lesions with a thrombectomy device in 62 patients who underwent emergent coronary intervention for the treatment of acute (<24 hours) or recent (24∼72 hours) ST-segment-elevation myocardial infarction (44 male, 18 female, age 68.0±19.3 years). Immunohistological analysis of aspirated thrombotic materials revealed that the content of platelets, as determined by immunostaining for CD42a, had a negative correlation with the time after the onset of chest pain (correlation coefficient: −0.683, p<0.01). Immunofluorescent staining for CD34 and breast cancer resistant protein-1 (bcrp-1) detected primitive cells in intracoronary thrombi. Furthermore, as shown in the figure, BNPthe ratio of CD34-positive cells in intracoronary thrombi had a significant positive correlation with restenosis at follow-up coronary angiography (correlation coefficient: 0.76, p=0.01).
Conclusions Findings of this study indicate that early accumulation of primitive cells in platelet aggregates may play a role in neointimal growth after successful coronary intervention in patients with acute coronary syndrome.
- © 2010 by American Heart Association, Inc.