Abstract 19682: Relationship between Markers of Endothelial Dysfunction and Cardiovascular Mortality
Background: Animal studies show that endothelial dysfunction may have a causative role in the development of cardiovascular disease (CVD). However, in humans, it is unclear whether markers of endothelial dysfunction such as intercellular adhesion molecule 1 (ICAM-1) and vascular adhesion molecule 1 (VCAM-1) are independently associated with CVD mortality.
Hypothesis: We examined the hypothesis that higher levels of VCAM and ICAM-1 are positively associated with CVD mortality.
Methods: We conducted a population-based, longitudinal cohort study in Beaver Dam, Wisconsin among 1755 subjects aged 44-85 years (56% women). Serum VCAM and ICAM-1 were examined as quartiles (VCAM quartiles 1-4: 0-661.4 ng/ml, 661.5-784.2 ng/ml, 784.3-944.6 ng/ml and >944.6 ng/ml; ICAM quartiles 1-4: 0-237.5 ng/ml, 237.6-281.8 ng/ml, 281.9-334.6 ng/ml and >334.6 ng/ml. The main outcome of interest was CVD mortality (n=323), including mortality from coronary heart disease and stroke.
Results: Overall, we observed a positive association between increasing quartiles of VCAM and ICAM with CVD mortality, independent of age, sex, education categories, smoking, alcohol intake, body mass index, diabetes mellitus, glycosylated hemoglobin, hypertension, systolic and diastolic blood pressure, and serum total cholesterol. The multivariable odds ratio (95% confidence interval) of CVD mortality for VCAM quartiles 1 to 4 were 1.00 (referent), 1.28 (0.83-1.98), 1.67 (1.10-2.53) and 1.78 (1.17-2.70), p-trend<0.0029; and for ICAM quartiles 1 to 4 were 1.00 (referent), 1.22 (0.87-1.72), 1.07 (0.77-1.51) and 1.44 (1.03-1.99), p-trend=0.0622.
Conclusion: Markers of endothelial dysfunction are positively associated with CVD mortality.
- © 2010 by American Heart Association, Inc.